RESUMO
A survey on New Caledonia confirmed the occurrence of a previously reported syndrome of spastic paralysis among leprosy patients. Of 18 patients recorded as having frank spastic paraplegia, seven were examined neurologically, as well as 51 other patients with leprosy but not spastic paralysis, and 23 patients with tuberculosis. Significant hyperreflexia was fairly common among both Melanesian and European leprosy patients, but was totally absent among tuberculosis patients. This syndrome was clinically unrelated to foci of neurologic disease previously reported in the Pacific Basin on Guam, the Kii Peninsula of Japan, and New Guinea. It is probably more closely related to diseases reported in other parts of the world that are generally regarded as nutritional or toxic in origin. The syndrome is possibly related to sulfone treatment of leprosy, although this has not been reported in other areas of the world where sulfones are used in the treatment of leprosy.(AU)
Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Hanseníase/complicações , Espasticidade Muscular/etnologia , Manifestações Neurológicas , Japão , Hanseníase/tratamento farmacológico , Hanseníase/epidemiologia , Melanesia , Nova Guiné , Distúrbios Nutricionais , Sulfonas/uso terapêutico , Tuberculose/complicaçõesRESUMO
An analysis is mead of the records of 19 lepromatous cases who were discharged from a Leprosarium in 1949. All cases were M/I before treatment, and became negative after treatment with one or more of three sulphones, viz. Promin, Diasone, and Sulphetrone. The duration of treatment varied from 29 to 53 months, the average duration of treatment being 41 months. The average amount of drugs given in this time was 297 g of Promin, 263 g of Diasone and 157 g of Suophetrone(AU)
