RESUMO
Antipyrine elimination has been studied in 31 black Jamaican men, 10 non-smokers, 7 cigarette smokers, 5 marijuana smokers and 9 smokers of both marijuana and cigarettes. Use of both marijuana and tobacco was associated with shorter antipyrine half-lives and faster clearance, inferring faster metabolism. The order of magnitude was similar, and use of both drugs had an additive effect. Half-lives of those subjects who smoked marijuana and cigarettes were half as long as in non-smokers. These results may have important implications for other oxidised drugs, and smoking habits should be considered when choosing dose regimes for such drugs (AU)
Assuntos
Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Abuso de Maconha/metabolismo , Preparações Farmacêuticas/metabolismo , Tabagismo , Antipirina/metabolismo , JamaicaRESUMO
The half-life of antipyrine has been estimated from saliva samples in ten subjects by a gas chromatographic method. Half-life, apparent volume of distribution and total body clearance estimated from saliva and plasma concentrations of antipyrine are not significantly different. The concentration of antipyrine in saliva is independent of the flow rate within the range expected in healthy subjects in response to mechanical and sapid stimuli. Antipyrine estimation in saliva could facilitate many areas of pharmacokinetic research limited by the difficulty of obtaining serial plasma samples. (AU)