RESUMO
Oral glucose tolerance tests on Jamaican children after an average of 3 months treatment in a hospital for malnutrition suggested a diminished peripheral uptake of glucose. This was confirmed with intravenous glucose tolerance tests. Despite 3 months treatment on an optimal diet the children's plasma levels of immunoreactive insulin were still subnormal, and the insulin response to intravenous glucose was much less than in Jamaican children who had never been malnourished. This suggests that malnutrition may produce a permanent reduction in the capacity for insulin secretion (AU)
Assuntos
Humanos , Lactente , Masculino , Feminino , Insulina/sangue , Insulina/metabolismo , Transtornos da Nutrição do Lactente/metabolismo , Transtornos da Nutrição do Lactente/fisiopatologia , Transtornos da Nutrição do Lactente/terapia , Glicemia/metabolismo , Dietoterapia , Antígenos , Glucose/metabolismo , Glucose/farmacocinética , Teste de Tolerância a Glucose , Imunoensaio , Anticorpos Anti-Insulina , Taxa Secretória/efeitos dos fármacos , Estimulação Química , Fatores de Tempo , JamaicaRESUMO
When one looks back to 1922 when Banting and Best first discovered insulin, one cannot help but be impressed with the remarkable strides made towards an understaning of this complex disease. Research has extended from gene complex through the prediabetic concept to the final action of insulin on the tissues. To date however, nothing has been finally settled and we are probably no better off today than the time of Banting and Best (Summary)
