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Am J Hum Genet ; 63(6): 1839-51, Dec. 1998.
Artigo em Inglês | MedCarib | ID: med-1417

RESUMO

We analyzed the European genetic contribution to 10 populations of Africans descent in the United States (Maywood, Illinois; Detroit; New York; Philadelphia; Pittsburgh; Baltimore; Charleston, South Carolina; New Orleans; and Houston) and in Jamaica, using nine autosomal DNA markers. These markers either are population-specific or show frequency differences >45 percent between the parental populations and are thus especially informative for admixture. European genetic ancestry ranged from 6.8 percent (Jamaica) to 22.5 percent (New Orleans). The unique utility of these markers is reflected in the low variance associated with these admixture estimates (SEM 1.3 percent -2.7 percent). We also estimated the male and female European contribution to African Americans. on the basis of informative mtDNA (haplogroups H and L) and Y Alu polymorphic markers. Results indicate a sex-biased gene flow from Europeans, the male contribution being substantially greater that the female contribution. mtDNA haplogroups analysis shows no evidence of a significant maternal Amerindian contribution to any of the 10 populations. We detected significant nonrandom association between two markers located 22 cM apart (FY-null and AT3), most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations. The strength of this association and the substantial genetic distance between FY and AT3 emphasize the importance of admixed populations as a useful resources for mapping traits with different prevalence in two parental populations (AU)


Assuntos
Feminino , Humanos , Masculino , Alelos , Genética Populacional , /genética , África/etnologia , Elementos Alu/genética , Negro ou Afro-Americano , DNA Mitocondrial/genética , Europa (Continente)/etnologia , Frequência do Gene , Pool Gênico , Marcadores Genéticos , Haplótipos/genética , Jamaica , Desequilíbrio de Ligação , /classificação , Polimorfismo Genético , Razão de Masculinidade , Estados Unidos , Cromossomo Y/genética
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