RESUMO
An incidence of canine circumanal gland adenoma (CGA) is reported, apparently for the first time, in the island of Trinidad and Tobago. The case involved an 11-year-old Rottweiler dog which was presented in relatively good health except for noticeable masses around the perianal region. Apart from routine histopathological investigation which enabled a definitive diagnosis of CGA with secondary vascularization, analysis of the nuclear chromatin texture was performed on the digitalized images of both reserve and hepatoid cells of the neoplasm. The mean nuclear pixel intensity value of the images of processed CGA reserve cells was significantly lower than those of the processed CGA hepatoid cells (P<0.1). Our observation based on the texture analytical data suggests a high degree of rate of multiplication of the reserve cells at the expense of degenerating hepatoid cells. The relevance of this finding is discussed within the context of vascular supply to the neoplastic cells (AU)
Assuntos
Animais , Cães , Cães/anormalidades , Trinidad e Tobago , Neoplasias das Glândulas Anais/história , Neoplasias das Glândulas Anais/patologia , Mitose , Neoplasias de Tecido VascularAssuntos
21003 , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Lactente , Aberrações Cromossômicas , Síndrome de Budd-Chiari/genética , Intoxicação por Plantas/genética , Hepatomegalia/genética , Fibroblastos/citologia , Síndrome de Budd-Chiari/induzido quimicamente , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Doença Hepática Induzida por Substâncias e Drogas/genética , Jamaica , Plantas Medicinais , Linfócitos/citologia , Mitose , Alcaloides de PirrolizidinaRESUMO
In the study factors which influence the growth of any tissue, a distinction must be made between determination, the decision as to which of the inherent genetic potentialities a given tissue will realize, and differentiation, the realization of expression of a specific potentiality. In the two tissue systems that are involved in the morphogenesis of the skull namely, synchondroses and syndesmoses, mitosis seems to have an essential place in between the act of determination and the process of differentiation. Mitosis is the first visible sign that a determination has occurred, and it precedes the final differentiation which results in deposition of bone or hypertrophy of cartilage. We have been using tritiated thymidine autoradiography to label pre-mitotic cells in the periodontal ligament (a syndesmosis) and in the spheno-occipital synchondrosis in the rat. In the case of the synchondrosis, growth of the adjacent basal bones can be directly related to mitosis within the cartilage between 40 and 80 days of age by calculations comparable to those of Kember. However, between 1 and 40 days, there is more growth than can be accounted for on the basis of mitoses detected within the cartilage. On the other hand, if one calculates the portion of growth due to endochondral replacement alone, interstitial mitoses in the cartilage are found to be adequate. Perichondral apposition of cartilage cells need not be postulated. The remaining portion of the total growth of the bones is accounted for by apposition of bone from the periosteum (AU)
