Assuntos
Epidemiologia , Emergências , Encefalite , Rhabdoviridae , Mpox , Orthobunyavirus , Vesiculovirus , HanseníaseRESUMO
The involvement of the central nervous system in dengue-affected children, the spectrum of neurological manifestations and the presence of dengue-specific IgM antibodies in the cerebrospinal fluid (CSF) was studied. A prospective study was conducted of all consecutive serum-positive dengue patients (n=100) admitted to the hospitals attached to the Jagadguru Jayadeva Murugharajendra Medical College, Davangere, Karnataka state, India, from January 2009 to September 2010. Children who presented with neurological symptoms were grouped separately and CSF was cultured and routine tests for cells, sugar, protein and chlorides were done. Further CSF was subjected for dengue IgM estimation. The study showed that the neurological incidence was 40%. Seizures were present in 70% of cases and altered sensorium was present in 80% of cases. Papilloedema and cranial nerve palsy were observed in 30% of cases and meningeal signs were present in 80% of cases. CSF protein was high in 80% of cases and pleocytosis was present in 80% of cases. CSF IgM was positive in 35% of cases. The mortality observed in this study was 4%. It was concluded that dengue fever encompasses an expanding clinical spectrum and is not just restricted to the WHO-specified criteria for making a diagnosis of dengue fever other than dengue haemorrhagic fever and dengue shock syndrome. It frequently causes encephalitis probably due to a direct neurotropic effect of dengue virus.
Assuntos
Dengue , Dengue , EncefaliteRESUMO
Dengue Bulletin. 2006 Dec;30:107-113.
Assuntos
Dengue , Encefalite , Miosite , Encefalopatia Hepática , ÍndiaRESUMO
This study examined all cases of tuberculous meningoencephalitis admitted to Ibn El-Khateeb Hospital for Infectious Diseases in Baghdad from 1993 to 1999. The diagnosis was based on the patient's history, clinical findings, cerebrospinal fluid analysis, microbial isolation and response to antitubercular drug therapy. The findings for cases diagnosed with tuberculous meningoencephalitis were compared with other types of meningitis. There were 224 cases comprising 5% of the total number of meningitis cases admitted during this period. The male to female ratio was 1.4:1. The age range was from 6 months to 72 years and the overall case fatality rate was 21%