Your browser doesn't support javascript.
loading
Risk factors for the prognosis of pediatric medulloblastoma: a retrospective analysis of 40 cases
Yu, Jianzhong; Zhao, Rui; Shi, Wei; Li, Hao.
Afiliação
  • Yu, Jianzhong; Children’s Hospital of Fudan University. Department of Neurosurgery. Shanghai. CN
  • Zhao, Rui; Children’s Hospital of Fudan University. Department of Neurosurgery. Shanghai. CN
  • Shi, Wei; Children’s Hospital of Fudan University. Department of Neurosurgery. Shanghai. CN
  • Li, Hao; Children’s Hospital of Fudan University. Department of Neurosurgery. Shanghai. CN
Clinics ; 72(5): 294-304, May 2017. tab, graf
Article em En | LILACS | ID: biblio-840077
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

In this study, we evaluated the association of molecular subtypes, clinical characteristics and pathological types with the prognosis of patients with medulloblastoma.

METHODS:

We analyzed forty patients with medulloblastoma who underwent surgical resection at our center between January 2004 and June 2014. Risk factors associated with survival, disease progression and recurrence were analyzed with a univariate Cox regression analysis, and the identified significant risk factors were further analyzed by Kaplan-Meier survival curves.

RESULTS:

Factors associated with overall survival included M stage (p=0.014), calcification (p=0.012), postoperative treatment, postoperative Karnofsky Performance Scale (KPS) score (p=0.015), and molecular subtype (p=0.005 for WNT and p=0.008 for SHH). Number of symptoms (p=0.029), M stage (p<0.001), and postoperative radiotherapy (p=0.033) were associated with disease progression. Patients with the WNT or SHH subtype had better survival outcomes than patients with non-WNT/SHH subtypes. Risk factors for disease progression-free survival were symptoms >2 and ≥M1 stage without postoperative radiotherapy. The risk of recurrence increased with advanced M stage. Protective factors for recurrence included M0 stage and a combination of chemotherapy and radiotherapy.

CONCLUSION:

We identified the risk factors associated with survival, disease progression and recurrence of medulloblastoma patients. This information is helpful for understanding the prognostic factors related to medulloblastoma.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Cerebelares / Meduloblastoma Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Cerebelares / Meduloblastoma Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Brasil