Evaluation of in vitro percutaneous enhancement effect of papain and pequi oil on diclofenac sodium permeation thourgh human skin
Rev. bras. ciênc. farm
; 44(2): 225-231, 2008. tab; graf
Artigo
em Inglês
| ACERVOFAR, FIOCRUZ
| ID: far-503
Biblioteca responsável:
BR526.1
Localização: ACERVOFAR; Rev. bras. ciênc. farm;44(2): 225-231, 2008
ABSTRACT
The purpose was to determine the potential of papain and pequi oil as penetration enhancers for diclofenac sodium (DS) across human skin in vitro. The permeation studies were conducted with vertical diffusion cells. The enhancers were associated or not in gels in different concentrations. In vitro studies reveled that papain 0.2% (w/v) presented an elevated enhancer property for diclofenac sodium (j=0.3369 μg/cm²xh). Pequi oil 10% (w/v) generated a reduced flux value (j=0.1848 μg/cm²xh) and a combination of both enhancers presented a medium value of j=0.2187 μg/cm²xh. Papain was found to be better enhancer than pequi oil(AU)
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Base de dados:
ACERVOFAR
/
FIOCRUZ
Assunto principal:
Papaína
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. ciênc. farm
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
Sorocaba University/Brasil
/
University of São Paulo/Brasil