Variants in phospholipid metabolism and upstream regulaltors and non-small cell lung cancer susceptibility
Clin. transl. oncol. (Print)
; 16(1): 107-112, ene. 2014. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-127528
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
AIM:
The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer.METHODS:
Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls.RESULTS:
Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies.CONCLUSIONS:
Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer (AU)RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Haplótipos
/
Colina Quinase
/
Carcinoma Pulmonar de Células não Pequenas
/
Proteína rhoB de Ligação ao GTP
/
Polimorfismo de Nucleotídeo Único
/
Neoplasias Pulmonares
Tipo de estudo:
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Andalusian School of Public Health/Spain
/
Catalan Institute of Oncology/Spain
/
Hospital General Universitario de Valencia/Spain
/
Murcia Regional Health Authority/Spain
/
Navarre Public Health Institute/Spain
/
Public Health Directorate Asturias/Spain
/
Public Health Division of Gipuzkoa (BIODONOSTIA)/Spain
/
University Hospital Fundación Jiménez Díaz/Spain