Synchronous versus metachronous brain metastasis from testicular germ cell tumors (TGCT): an analysis from the Spanish Germ Cell Cancer Group data base
Clin. transl. oncol. (Print)
; 16(11): 959-965, nov. 2014.
Artigo
em Inglês
| IBECS
| ID: ibc-128636
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Brain metastases of testicular germ cell tumor (TGCT) are a rare event. Prognostic is poor and there is not much evidence on optimal management of these patients. PATIENTS ANDMETHODS:
A review of case records of germ cell tumor patients within the Spanish Germ Cell Cancer Group data base from 1994 to 2012 was conducted.RESULTS:
Thirty-three out of 6,200 cases (0.5 %). Nineteen patients (57 %) group 1 synchronous, 13 (40 %) group 2 metachronous and only one developed brain metastasis during cisplatin-based chemotherapy (excluded from the analysis). Median serum BHCG levels at initial diagnosis was higher in group 1, whereas elevated AFP serum levels were more common in group 2. Histology in the primary tumor chorionic carcinoma for group 1 versus embryonal carcinoma for group 2. Mainly solitary brain metastasis in group 2 (54 versus 21 %, respectively). The median overall survival from the diagnosis of central nervous system involvement was 16 months for group 1 (CI 95 % 13.9-18) and 23 months (95 % CI 0-165) for group 2 (log rank p = 0.84). Long-term survivors were practically identical in the two groups (38.9 % group 1 versus 38.5 % group 2). Regardless of the timing of brain metastasis, those patients that achieved complete response to the treatment had better survival (log rank p 0.003).CONCLUSION:
Although some distinctive clinical characteristics have been found between patients with synchronous versus metachronous brain metastasis from TGCT, the timing of brain metastasis did not seem to have prognostic influence, but due to the retrospective nature of the analysis and the results should be interpreted with caution (AU)RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Testiculares
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Neoplasias Encefálicas
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Segunda Neoplasia Primária
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Neoplasias Primárias Múltiplas
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Clínico San Carlos/Spain
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Hospital Clínico de Zaragoza/Spain
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Hospital Doctor Peset Valencia/Spain
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Hospital Gregorio Marañón/Spain
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Hospital La Fe/Spain
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Hospital Lluis Alcanyis Xàtiva/Spain
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Hospital Lucus Augusti/Spain
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Hospital Marqués de Valdecilla/Spain
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Hospital Morales Meseguer/Spain
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Hospital Parc Taulí/Spain