Lifetime psychopathology among the offspring of Bipolar I parents
Clinics
; 66(5): 725-730, 2011. tab
Artigo
em Inglês
| LILACS
| ID: lil-593831
Biblioteca responsável:
BR1.1
ABSTRACT
BACKGROUND:
Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents.METHOD:
This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated.RESULTS:
Of the offspring studied, 71.4 percent had a lifetime diagnosis of at least one psychiatric disorder (28.6 percent with a mood disorder, 40 percent with a disruptive behavior disorder and 20 percent with an anxiety disorder). Pure mood disorders (11.4 percent) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1 percent). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4 percent).CONCLUSIONS:
Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Pais
/
Transtorno Bipolar
/
Filho de Pais Incapacitados
/
Transtornos Mentais
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Federal University of São Paulo/BR
/
The University of Texas/US
/
Universidade de São Paulo/BR
/
University of Texas Health/US