Performance of a rapid diagnostic test for the detection of visceral leishmaniasis in a large urban setting
Rev. Soc. Bras. Med. Trop
; 46(5): 589-593, Sept-Oct/2013. tab
Artigo
em Inglês
| LILACS
| ID: lil-691425
Biblioteca responsável:
BR1.1
ABSTRACT
Introduction Rapid diagnostic tests (RDTs) may improve the early detection of visceral leishmaniasis (VL), but their real-world performance requires additional study. Therefore, we evaluated the performance of an rK39-based RDT (Kalazar Detect™) for the detection of VL in an endemic, large urban area. Methods Data were collected from a registry of rK39 RDT performed at 11 emergency care units in Belo Horizonte, Brazil, and from a national database of reportable communicable diseases of the Sistema de Informação de Agravos de Notificação (SINAN). Results The rapid rK39 test was performed in 476 patients, with 114 (23.9%) positive results. The analysis of rK39 RDT performance was based on 381 (80%) cases reported to the SINAN database, of which 145 (38.1%) were confirmed cases. Estimates for sensitivity and specificity were 72.4% (95% CI 64.6-79%) and 99.6% (95%CI 97.6-99.9%), respectively. Positive and negative predictive values were estimated at 99.1% (95%CI 94.9-99.8%) and 85.5% (95%CI 80.8-89.1%), respectively. In addition, close agreement between the rK39 RDT and indirect immunofluorescence was observed. Conclusions In summary, the rK39 RDT showed a high specificity but only moderate sensitivity. In endemic areas for VL, treatment may be considered in cases with clinical manifestations and a positive rK39 RDT, but those with a negative test should be subjected to further investigation. .
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 6: Sistemas de informação em saúde
Base de dados:
LILACS
Assunto principal:
Kit de Reagentes para Diagnóstico
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Leishmania donovani
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Anticorpos Antiprotozoários
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Proteínas de Protozoários
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Leishmaniose Visceral
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Antígenos de Protozoários
Tipo de estudo:
Estudo diagnóstico
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Estudo de avaliação
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Estudo prognóstico
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Estudo de rastreamento
Limite:
Adolescente
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Adulto
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Idoso
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Idoso, 80 anos ou mais
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Criança
/
Criança, pré-escolar
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Feminino
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Humanos
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Lactente
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Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Prefeitura Municipal/BR