Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática / Cardiac adverse effects of domperidone in adult patients: a systematic review
Rev. méd. Chile
; 143(1): 14-21, ene. 2015. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-742546
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported.Aim:
To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material andMethods:
Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction.Results:
Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI) 1.4-16), 1.59 (95% CI 1.28-1.98) and 11.02 (95% CI 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day.Conclusions:
Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Neoplasia da Mama
Base de dados:
LILACS
Assunto principal:
Neoplasias da Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Paclitaxel
/
Diterpenos
/
Compostos de Epóxi
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Revisão sistemática
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad Nacional de Rosario/AR