Ligustrazini inhibits endotoxin induced PAI-1 expression in human umbilical vein endothelial cells.
J Tongji Med Univ
; 21(1): 6-7, 16, 2001.
Article
em En
| MEDLINE
| ID: mdl-11523251
ABSTRACT
Plasminogen activator inhibitor 1 (PAI-1) is one of important coagulant factors. Endotoxin lipopolysaccharide (LPS) induces thrombosis by stimulating PAI-1 secretion of vascular cells (EC). Using sandwich enzyme-linked immunosorbent assay (ELISA) and Northern blot, was investigated the effects of Chinese medicine ligustrazini on PAI-1 expression in EC and LPS-stimulated EC. The results showed that ligustrazini inhibited both basal and LPS-induced PAI-1 mRNA expression in EC. The effect of ligustrazini on LPS-induced PAI-1 secretion worked in a dose-dependent manner. This study provided theoretic and experimental evidence for use of ligustrazini against septic shock and cardiovascular diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Endotélio Vascular
/
Anti-Inflamatórios não Esteroides
/
Inibidor 1 de Ativador de Plasminogênio
Limite:
Humans
Idioma:
En
Revista:
J Tongji Med Univ
Assunto da revista:
MEDICINA
Ano de publicação:
2001
Tipo de documento:
Article