Heterozygous mutation (G/GâG/A) at nt 2607 of the EGFR gene is closely associated with increases in EGFR copy number and mRNA half life, but impaired EGFR protein synthesis in squamous cell carcinomas of the head and neck - implication for gefitinib efficacy.

Nakazaki, Kouichi; Kato, Yasumasa; Taguchi, Takahide; Inayama, Yoshizaki; Ishiguro, Yukari; Kondo, Norio; Horiuchi, Chouichi; Sakakibara, Atuko; Tsukuda, Mamoru

Heterozygous mutation (G/GâG/A) at nt 2607 of the EGFR gene is closely associated with increases in EGFR copy number and mRNA half life, but impaired EGFR protein synthesis in squamous cell carcinomas of the head and neck - implication for gefitinib efficacy.

Nakazaki, Kouichi; Kato, Yasumasa; Taguchi, Takahide; Inayama, Yoshizaki; Ishiguro, Yukari; Kondo, Norio; Horiuchi, Chouichi; Sakakibara, Atuko; Tsukuda, Mamoru.

Afiliação

Nakazaki K; Department of Otorhinolaryngology, Shonan General Hospital, Yokosuka 237-0067.

Oncol Lett ; 1(6): 1017-1020, 2010 Nov.

Article em En | MEDLINE | ID: mdl-22870104

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Oncol Lett Ano de publicação: 2010 Tipo de documento: Article País de publicação: Grécia

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