MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis.

Podrini, Christine; Koffas, Apostolos; Chokshi, Shilpa; Vinciguerra, Manlio; Lelliott, Christopher J; White, Jacqueline K; Adissu, Hibret A; Williams, Roger; Greco, Azzura

Podrini, Christine; Koffas, Apostolos; Chokshi, Shilpa; Vinciguerra, Manlio; Lelliott, Christopher J; White, Jacqueline K; Adissu, Hibret A; Williams, Roger; Greco, Azzura.

Afiliação

Podrini C; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Koffas A; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Chokshi S; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Vinciguerra M; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Lelliott CJ; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
White JK; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Adissu HA; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Williams R; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,
Greco A; *Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge,

FASEB J ; 29(5): 1676-87, 2015 May.

Article em En | MEDLINE | ID: mdl-25526730

Assuntos

Biomarcadores/metabolismo; Carcinoma Hepatocelular/patologia; Dieta Hiperlipídica/efeitos adversos; Epigenômica; Fígado Gorduroso/metabolismo; Fígado Gorduroso/patologia; Hepatócitos/patologia; Histonas/metabolismo; Animais; Western Blotting; Carcinoma Hepatocelular/metabolismo; Células Cultivadas; Imunoprecipitação da Cromatina; Fígado Gorduroso/etiologia; Feminino; Imunofluorescência; Perfilação da Expressão Gênica; Hepatócitos/metabolismo; Histonas/genética; Humanos; Técnicas Imunoenzimáticas; Peroxidação de Lipídeos; Fígado/metabolismo; Fígado/patologia; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; ATPases Mitocondriais Próton-Translocadoras/fisiologia; Análise de Sequência com Séries de Oligonucleotídeos; Regiões Promotoras Genéticas/genética; Isoformas de Proteínas; RNA Mensageiro/genética; Reação em Cadeia da Polimerase em Tempo Real; Reação em Cadeia da Polimerase Via Transcriptase Reversa

Palavras-chave

bivalent promoter; histone methylation; histone variants; lipid uptake

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Biomarcadores / Carcinoma Hepatocelular / Hepatócitos / Fígado Gorduroso / Epigenômica / Dieta Hiperlipídica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos

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