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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.
Vilums, Maris; Zweemer, Annelien J M; Barmare, Farhana; van der Gracht, Anouk M F; Bleeker, Dave C T; Yu, Zhiyi; de Vries, Henk; Gross, Raymond; Clemens, Jeremy; Krenitsky, Paul; Brussee, Johannes; Stamos, Dean; Saunders, John; Heitman, Laura H; IJzerman, Adriaan P.
Afiliação
  • Vilums M; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • Zweemer AJ; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • Barmare F; Vertex Pharmaceuticals Incorporated, 11010 Torreyana Rd., San Diego, CA 92121, USA.
  • van der Gracht AM; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • Bleeker DC; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • Yu Z; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • de Vries H; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • Gross R; Vertex Pharmaceuticals Incorporated, 11010 Torreyana Rd., San Diego, CA 92121, USA.
  • Clemens J; Vertex Pharmaceuticals Incorporated, 11010 Torreyana Rd., San Diego, CA 92121, USA.
  • Krenitsky P; Vertex Pharmaceuticals Incorporated, 11010 Torreyana Rd., San Diego, CA 92121, USA.
  • Brussee J; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • Stamos D; Vertex Pharmaceuticals Incorporated, 11010 Torreyana Rd., San Diego, CA 92121, USA.
  • Saunders J; Vertex Pharmaceuticals Incorporated, 11010 Torreyana Rd., San Diego, CA 92121, USA.
  • Heitman LH; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
  • IJzerman AP; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. Electronic address: ijzerman@lacdr.leidenuniv.nl.
Eur J Med Chem ; 93: 121-34, 2015 Mar 26.
Article em En | MEDLINE | ID: mdl-25666912
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quimiocina CCL2 / Ciclopentanos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quimiocina CCL2 / Ciclopentanos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda País de publicação: França