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Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.
Dong, Junchao; Panchakshari, Rohit A; Zhang, Tingting; Zhang, Yu; Hu, Jiazhi; Volpi, Sabrina A; Meyers, Robin M; Ho, Yu-Jui; Du, Zhou; Robbiani, Davide F; Meng, Feilong; Gostissa, Monica; Nussenzweig, Michel C; Manis, John P; Alt, Frederick W.
Afiliação
  • Dong J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Panchakshari RA; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Zhang T; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Zhang Y; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Hu J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Volpi SA; Boston Children's Hospital and Joint Program in Transfusion Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Meyers RM; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Ho YJ; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Du Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Robbiani DF; Howard Hughes Medical Institute, Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Meng F; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Gostissa M; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Nussenzweig MC; Howard Hughes Medical Institute, Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Manis JP; Boston Children's Hospital and Joint Program in Transfusion Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Nature ; 525(7567): 134-139, 2015 Sep 03.
Article em En | MEDLINE | ID: mdl-26308889
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Regiões Constantes de Imunoglobulina / Cadeias Pesadas de Imunoglobulinas / Switching de Imunoglobulina / Citidina Desaminase / Reparo do DNA / Quebras de DNA de Cadeia Dupla Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Regiões Constantes de Imunoglobulina / Cadeias Pesadas de Imunoglobulinas / Switching de Imunoglobulina / Citidina Desaminase / Reparo do DNA / Quebras de DNA de Cadeia Dupla Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido