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Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.
Liu, Chunjian; Lin, James; Hynes, John; Wu, Hong; Wrobleski, Stephen T; Lin, Shuqun; Dhar, T G Murali; Vrudhula, Vivekananda M; Sun, Jung-Hui; Chao, Sam; Zhao, Rulin; Wang, Bei; Chen, Bang-Chi; Everlof, Gerry; Gesenberg, Christoph; Zhang, Hongjian; Marathe, Punit H; McIntyre, Kim W; Taylor, Tracy L; Gillooly, Kathleen; Shuster, David J; McKinnon, Murray; Dodd, John H; Barrish, Joel C; Schieven, Gary L; Leftheris, Katerina.
Afiliação
  • Liu C; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Lin J; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Hynes J; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Wu H; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Wrobleski ST; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Lin S; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Dhar TG; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Vrudhula VM; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Sun JH; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Chao S; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Zhao R; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Wang B; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Chen BC; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Everlof G; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Gesenberg C; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Zhang H; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Marathe PH; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • McIntyre KW; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Taylor TL; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Gillooly K; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Shuster DJ; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • McKinnon M; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Dodd JH; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Barrish JC; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Schieven GL; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
  • Leftheris K; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.
J Med Chem ; 58(19): 7775-84, 2015 Oct 08.
Article em En | MEDLINE | ID: mdl-26359680

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilacetatos / Organofosfatos / Pró-Fármacos / Inibidores de Proteínas Quinases Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilacetatos / Organofosfatos / Pró-Fármacos / Inibidores de Proteínas Quinases Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos