Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells.

Lin, Renyu; Zhang, Ziheng; Chen, Lingfeng; Zhou, Yunfang; Zou, Peng; Feng, Chen; Wang, Li; Liang, Guang

Lin, Renyu; Zhang, Ziheng; Chen, Lingfeng; Zhou, Yunfang; Zou, Peng; Feng, Chen; Wang, Li; Liang, Guang.

Afiliação

Lin R; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Otorhinolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhang Z; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Otorhinolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Chen L; School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.
Zhou Y; Department of Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang 323000, China.
Zou P; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.
Feng C; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wang L; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: wzmuwangli@163.com.
Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. Electronic address: wzmcliangguang@163.c

Cancer Lett ; 381(1): 165-75, 2016 10 10.

Article em En | MEDLINE | ID: mdl-27477901

Assuntos

Inibidores da Angiogênese/farmacologia; Apoptose/efeitos dos fármacos; Artemisininas/farmacologia; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Neoplasias de Cabeça e Pescoço/tratamento farmacológico; Proteínas Angiogênicas/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Proteína Forkhead Box M1/genética; Proteína Forkhead Box M1/metabolismo; Neoplasias de Cabeça e Pescoço/genética; Neoplasias de Cabeça e Pescoço/metabolismo; Neoplasias de Cabeça e Pescoço/patologia; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Neovascularização Patológica; Neovascularização Fisiológica/efeitos dos fármacos; Interferência de RNA; Transdução de Sinais/efeitos dos fármacos; Fatores de Tempo; Transfecção

Palavras-chave

Antitumor; Cell cycle; Dihydroartemisinin; Ferroptosis; Head and neck cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Inibidores da Angiogênese / Artemisininas / Pontos de Checagem do Ciclo Celular / Neoplasias de Cabeça e Pescoço Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Irlanda

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