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Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.
Liang, Qiming; Luo, Zhifei; Zeng, Jianxiong; Chen, Weiqiang; Foo, Suan-Sin; Lee, Shin-Ae; Ge, Jianning; Wang, Su; Goldman, Steven A; Zlokovic, Berislav V; Zhao, Zhen; Jung, Jae U.
Afiliação
  • Liang Q; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electro
  • Luo Z; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Zeng J; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Chen W; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Foo SS; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Lee SA; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Ge J; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Wang S; Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA; Department of Neurology, University of Rochester, Rochester, NY 14642, USA; Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark.
  • Goldman SA; Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA; Department of Neurology, University of Rochester, Rochester, NY 14642, USA; Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark.
  • Zlokovic BV; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Zhao Z; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: zzhao@usc.edu.
  • Jung JU; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: jaeujung@med.usc.edu.
Cell Stem Cell ; 19(5): 663-671, 2016 11 03.
Article em En | MEDLINE | ID: mdl-27524440
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas não Estruturais Virais / Proteínas Proto-Oncogênicas c-akt / Neurogênese / Células-Tronco Neurais / Serina-Treonina Quinases TOR / Feto / Zika virus Limite: Animals / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas não Estruturais Virais / Proteínas Proto-Oncogênicas c-akt / Neurogênese / Células-Tronco Neurais / Serina-Treonina Quinases TOR / Feto / Zika virus Limite: Animals / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos