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Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.
Huang, Richard Y-C; Iacob, Roxana E; Krystek, Stanley R; Jin, Mi; Wei, Hui; Tao, Li; Das, Tapan K; Tymiak, Adrienne A; Engen, John R; Chen, Guodong.
Afiliação
  • Huang RY; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
  • Iacob RE; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA.
  • Krystek SR; Molecular Structure and Design, Research and Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
  • Jin M; Biologics Development and Operations, Global Manufacturing & Supply, Bristol-Myers Squibb Company, 6000 Thompson Road, Syracuse, NY, 13057, USA.
  • Wei H; Biologics Development and Operations, Global Manufacturing & Supply, Bristol-Myers Squibb Company, 311 Pennington-Rocky Hill Road, Hopewell, NJ, 08534, USA.
  • Tao L; Biologics Development and Operations, Global Manufacturing & Supply, Bristol-Myers Squibb Company, 311 Pennington-Rocky Hill Road, Hopewell, NJ, 08534, USA.
  • Das TK; Biologics Development and Operations, Global Manufacturing & Supply, Bristol-Myers Squibb Company, 311 Pennington-Rocky Hill Road, Hopewell, NJ, 08534, USA.
  • Tymiak AA; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
  • Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA.
  • Chen G; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ, 08543, USA. guodong.chen@bms.com.
J Am Soc Mass Spectrom ; 28(5): 795-802, 2017 05.
Article em En | MEDLINE | ID: mdl-27527097
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Imunoglobulina G / Fragmentos Fc das Imunoglobulinas / Agregados Proteicos Limite: Humans Idioma: En Revista: J Am Soc Mass Spectrom Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Imunoglobulina G / Fragmentos Fc das Imunoglobulinas / Agregados Proteicos Limite: Humans Idioma: En Revista: J Am Soc Mass Spectrom Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos