Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates.

Sanllehí, Pol; Abad, José-Luís; Bujons, Jordi; Casas, Josefina; Delgado, Antonio

Sanllehí, Pol; Abad, José-Luís; Bujons, Jordi; Casas, Josefina; Delgado, Antonio.

Afiliação

Sanllehí P; Spanish National Research Council (CSIC), Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Research Unit on Bioactive Molecules (RUBAM), Department of Biomedicinal Chemistry, Jordi Girona 18-26, 08034, Barcelona, Spain; University of Barcelona (UB), Faculty of Pharmacy, Department of Pharma
Abad JL; Spanish National Research Council (CSIC), Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Research Unit on Bioactive Molecules (RUBAM), Department of Biomedicinal Chemistry, Jordi Girona 18-26, 08034, Barcelona, Spain.
Bujons J; Spanish National Research Council (CSIC), Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry and Molecular Modelling, Jordi Girona 18-26, 08034, Barcelona, Spain.
Casas J; Spanish National Research Council (CSIC), Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Research Unit on Bioactive Molecules (RUBAM), Department of Biomedicinal Chemistry, Jordi Girona 18-26, 08034, Barcelona, Spain.
Delgado A; Spanish National Research Council (CSIC), Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Research Unit on Bioactive Molecules (RUBAM), Department of Biomedicinal Chemistry, Jordi Girona 18-26, 08034, Barcelona, Spain; University of Barcelona (UB), Faculty of Pharmacy, Department of Pharma

Eur J Med Chem ; 123: 905-915, 2016 Nov 10.

Article em En | MEDLINE | ID: mdl-27543882

Assuntos

Aldeído Liases/antagonistas & inibidores; Azidas/química; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Fosfatos/química; Fosfatos/farmacologia; Aldeído Liases/química; Aldeído Liases/metabolismo; Estabilidade de Medicamentos; Inibidores Enzimáticos/metabolismo; Humanos; Simulação de Acoplamento Molecular; Fosfatos/metabolismo; Conformação Proteica; Estereoisomerismo

Palavras-chave

Enzyme inhibitor; Sphingolipids; Sphingosine lyase; Stereocontrolled; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Azidas / Aldeído Liases / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2016 Tipo de documento: Article País de publicação: França

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