Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox.

Zhu, Xudong; Huang, Lingli; Xu, Yamei; Xie, Shuyu; Pan, Yuanhu; Chen, Dongmei; Liu, Zhenli; Yuan, Zonghui

Zhu, Xudong; Huang, Lingli; Xu, Yamei; Xie, Shuyu; Pan, Yuanhu; Chen, Dongmei; Liu, Zhenli; Yuan, Zonghui.

Afiliação

Zhu X; a MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products , Huazhong Agricultural University , Wuhan , China.
Huang L; a MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products , Huazhong Agricultural University , Wuhan , China.
Xu Y; b National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , China.
Xie S; b National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , China.
Pan Y; b National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , China.
Chen D; b National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , China.
Liu Z; b National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , China.
Yuan Z; b National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , China.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess ; 34(2): 192-210, 2017 Feb.

Article em En | MEDLINE | ID: mdl-28001497

Assuntos

Modelos Biológicos; Quinoxalinas/farmacocinética; Suínos/metabolismo; Animais; Resíduos de Drogas/química; Resíduos de Drogas/metabolismo; Resíduos de Drogas/farmacocinética; Simulação de Dinâmica Molecular; Método de Monte Carlo; Quinoxalinas/análise; Quinoxalinas/metabolismo

Palavras-chave

Monte Carlo analysis; PBPK model; cross-compound extrapolation; mequindox; quinocetone; residue prediction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Suínos / Modelos Biológicos Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Animals Idioma: En Revista: Food Addit Contam Part A Chem Anal Control Expo Risk Assess Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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