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The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Pajtler, Kristian W; Sadowski, Natalie; Ackermann, Sandra; Althoff, Kristina; Schönbeck, Kerstin; Batzke, Katharina; Schäfers, Simon; Odersky, Andrea; Heukamp, Lukas; Astrahantseff, Kathy; Künkele, Annette; Deubzer, Hedwig E; Schramm, Alexander; Sprüssel, Annika; Thor, Theresa; Lindner, Sven; Eggert, Angelika; Fischer, Matthias; Schulte, Johannes H.
Afiliação
  • Pajtler KW; Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Republic of Korea.
  • Sadowski N; Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Heidelberg, Germany.
  • Ackermann S; German Cancer Consortium (DKTK Core Center Heidelberg), Germany.
  • Althoff K; Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.
  • Schönbeck K; Department of Pediatric Oncology and Hematology, University Children's Hospital, and Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Batzke K; Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.
  • Schäfers S; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.
  • Odersky A; Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.
  • Heukamp L; Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.
  • Astrahantseff K; Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.
  • Künkele A; NEO New Oncology, Cologne, Germany.
  • Deubzer HE; Institute for Hematopathology, Hamburg, Germany.
  • Schramm A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.
  • Sprüssel A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.
  • Thor T; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.
  • Lindner S; Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany.
  • Eggert A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany.
  • Fischer M; Berlin Institute of Health (BIH), Germany.
  • Schulte JH; German Cancer Consortium (DKTK Berlin), Germany.
Oncotarget ; 8(4): 6730-6741, 2017 Jan 24.
Article em En | MEDLINE | ID: mdl-28036269
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Benzimidazóis / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Inibidores de Proteínas Quinases / Neuroblastoma / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Benzimidazóis / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Inibidores de Proteínas Quinases / Neuroblastoma / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos