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Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Qin, Lan-Ying; Ruan, Zheming; Cherney, Robert J; Dhar, T G Murali; Neels, James; Weigelt, Carolyn A; Sack, John S; Srivastava, Anurag S; Cornelius, Lyndon A M; Tino, Joseph A; Stefanski, Kevin; Gu, Xiaomei; Xie, Jenny; Susulic, Vojkan; Yang, Xiaoxia; Yarde-Chinn, Melissa; Skala, Stacey; Bosnius, Ruth; Goldstein, Christine; Davies, Paul; Ruepp, Stefan; Salter-Cid, Luisa; Bhide, Rajeev S; Poss, Michael A.
Afiliação
  • Qin LY; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA. Electronic address: lan-ying.qin@bms.com.
  • Ruan Z; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Cherney RJ; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Dhar TGM; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Neels J; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Weigelt CA; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Sack JS; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Srivastava AS; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Cornelius LAM; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Tino JA; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Stefanski K; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Gu X; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Xie J; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Susulic V; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Yang X; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Yarde-Chinn M; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Skala S; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Bosnius R; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Goldstein C; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Davies P; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Ruepp S; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Salter-Cid L; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Bhide RS; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
  • Poss MA; Bristol-Myers Squibb, Rt. 206 & Province Line Road, Princeton, NJ 08540, USA.
Bioorg Med Chem Lett ; 27(4): 855-861, 2017 02 15.
Article em En | MEDLINE | ID: mdl-28108251
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Aminas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Aminas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido