The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia.

Qin, Ya-Zhen; Wang, Yu; Xu, Lan-Ping; Zhang, Xiao-Hui; Chen, Huan; Han, Wei; Chen, Yu-Hong; Wang, Feng-Rong; Wang, Jing-Zhi; Chen, Yao; Mo, Xiao-Dong; Zhao, Xiao-Su; Chang, Ying-Jun; Liu, Kai-Yan; Huang, Xiao-Jun

Qin, Ya-Zhen; Wang, Yu; Xu, Lan-Ping; Zhang, Xiao-Hui; Chen, Huan; Han, Wei; Chen, Yu-Hong; Wang, Feng-Rong; Wang, Jing-Zhi; Chen, Yao; Mo, Xiao-Dong; Zhao, Xiao-Su; Chang, Ying-Jun; Liu, Kai-Yan; Huang, Xiao-Jun.

Afiliação

Qin YZ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Wang Y; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Xu LP; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Zhang XH; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Chen H; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Han W; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Chen YH; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Wang FR; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Wang JZ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Chen Y; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Mo XD; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Zhao XS; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Chang YJ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Liu KY; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.
Huang XJ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China. xjhrm@medmail.com.cn.

J Hematol Oncol ; 10(1): 44, 2017 02 06.

Article em En | MEDLINE | ID: mdl-28166825

Assuntos

Cromossomos Humanos Par 21/ultraestrutura; Cromossomos Humanos Par 8/ultraestrutura; Subunidade alfa 2 de Fator de Ligação ao Core/biossíntese; Regulação Leucêmica da Expressão Gênica; Transplante de Células-Tronco Hematopoéticas; Leucemia Mieloide Aguda/genética; Proteínas de Fusão Oncogênica/biossíntese; RNA Mensageiro/biossíntese; RNA Neoplásico/biossíntese; Proteína 1 Parceira de Translocação de RUNX1/biossíntese; Translocação Genética; Adolescente; Adulto; Aloenxertos; Criança; Pré-Escolar; Cromossomos Humanos Par 21/genética; Cromossomos Humanos Par 8/genética; Subunidade alfa 2 de Fator de Ligação ao Core/genética; Feminino; Seguimentos; Humanos; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/terapia; Masculino; Pessoa de Meia-Idade; Neoplasia Residual; Proteínas de Fusão Oncogênica/genética; RNA Mensageiro/genética; RNA Neoplásico/genética; Proteína 1 Parceira de Translocação de RUNX1/genética; Recidiva; Adulto Jovem

Palavras-chave

Acute myeloid leukemia; Allogeneic hematopoietic stem cell transplantation; Donor lymphocyte infusion; RUNX1-RUNX1T1 transcript levels; Relapse

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Cromossomos Humanos Par 8 / Cromossomos Humanos Par 21 / RNA Mensageiro / RNA Neoplásico / Leucemia Mieloide Aguda / Regulação Leucêmica da Expressão Gênica / Proteínas de Fusão Oncogênica / Transplante de Células-Tronco Hematopoéticas / Subunidade alfa 2 de Fator de Ligação ao Core Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: J Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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