1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the ß-catenin/TCF4/GSK-3ß/mTOR pathway.

Wei, Huili; Qu, Hua; Wang, Hang; Ji, Baolan; Ding, Yao; Liu, Dan; Duan, Yang; Liang, Huimin; Peng, Chuan; Xiao, Xiaoqiu; Deng, Huacong

Wei, Huili; Qu, Hua; Wang, Hang; Ji, Baolan; Ding, Yao; Liu, Dan; Duan, Yang; Liang, Huimin; Peng, Chuan; Xiao, Xiaoqiu; Deng, Huacong.

Afiliação

Wei H; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China. Electronic address: whl880410@163.com.
Qu H; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China. Electronic address: 276647689@qq.com.
Wang H; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China. Electronic address: 373776507@qq.com.
Ji B; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China.
Ding Y; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China.
Liu D; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China.
Duan Y; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China.
Liang H; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China.
Peng C; Laboratory of Lipid and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xiao X; Laboratory of Lipid and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Deng H; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jiagang, Yuzhong District, Chongqing 400016, China. Electronic address: denghuacong_111@163.com.

J Steroid Biochem Mol Biol ; 168: 71-90, 2017 04.

Article em En | MEDLINE | ID: mdl-28216152

Assuntos

Autofagia/efeitos dos fármacos; Calcitriol/farmacologia; Cardiomiopatias Diabéticas/prevenção & controle; Transdução de Sinais; Animais; Pressão Sanguínea; Linhagem Celular; Linhagem Celular Tumoral; Proteínas de Ligação a DNA/metabolismo; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Relação Dose-Resposta a Droga; Ecocardiografia; Inativação Gênica; Glucose/metabolismo; Glicogênio Sintase Quinase 3 beta/metabolismo; Masculino; Ratos; Ratos Sprague-Dawley; Serina-Treonina Quinases TOR/metabolismo; Distribuição Tecidual; Fator de Transcrição 4; Fatores de Transcrição/metabolismo; beta Catenina/metabolismo

Palavras-chave

Autophagy; Diabetic cardiomyopathy; Type 1 diabetes; Vitamin D

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Calcitriol / Transdução de Sinais / Cardiomiopatias Diabéticas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido

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