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Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution.
García-Pupo, Laura; Sánchez, Jeney Ramírez; Ratman, Dariusz; Pérez-Novo, Claudina; Declerck, Ken; De Bosscher, Karolien; Markakis, Marios Nektarios; Beemster, Gerrit; Zaldo, Armando; Nuñez Figueredo, Yanier; Delgado-Hernández, René; Vanden Berghe, Wim.
Afiliação
  • García-Pupo L; Centro de Investigación y Desarrollo de Medicamentos (CIDEM), BioCubaFarma, Ave 26, No. 1605 Boyeros y Puentes Grandes, CP 10600 La Habana, Cuba. Electronic address: laura.garcia@cidem.cu.
  • Sánchez JR; Centro de Investigación y Desarrollo de Medicamentos (CIDEM), BioCubaFarma, Ave 26, No. 1605 Boyeros y Puentes Grandes, CP 10600 La Habana, Cuba. Electronic address: yeney.ramirez@cidem.cu.
  • Ratman D; Receptor Research Laboratories, Nuclear Receptor Lab, Medical Biotechnology Center, VIB, Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.
  • Pérez-Novo C; Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
  • Declerck K; Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
  • De Bosscher K; Receptor Research Laboratories, Nuclear Receptor Lab, Medical Biotechnology Center, VIB, Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.
  • Markakis MN; Integrated Molecular Plant Physiology Research (IMPRES), Department of Biology, University of Antwerp, Campus Groenenborger, Groenenborgerlaan 171 G.U.613, 2020 Antwerp, Belgium.
  • Beemster G; Integrated Molecular Plant Physiology Research (IMPRES), Department of Biology, University of Antwerp, Campus Groenenborger, Groenenborgerlaan 171 G.U.613, 2020 Antwerp, Belgium.
  • Zaldo A; Centro de Estudios de Productos Naturales, Facultad de Química, Universidad de la Habana, Zapata s/n entre G y Carlitos Aguirre, Vedado, Plaza de la Revolución, CP 10400 La Habana, Cuba. Electronic address: zaldo@fq.uh.cu.
  • Nuñez Figueredo Y; Centro de Investigación y Desarrollo de Medicamentos (CIDEM), BioCubaFarma, Ave 26, No. 1605 Boyeros y Puentes Grandes, CP 10600 La Habana, Cuba. Electronic address: yanier.nunez@cidem.cu.
  • Delgado-Hernández R; Centro de Investigación y Desarrollo de Medicamentos (CIDEM), BioCubaFarma, Ave 26, No. 1605 Boyeros y Puentes Grandes, CP 10600 La Habana, Cuba. Electronic address: rdelgado@infomed.sld.cu.
  • Vanden Berghe W; Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. Electronic address: wim.vandenberghe@uantwerpen.be.
Brain Behav Immun ; 64: 103-115, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28390980
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sapogeninas / Isquemia Encefálica / Fármacos Neuroprotetores / Acidente Vascular Cerebral / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Holanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sapogeninas / Isquemia Encefálica / Fármacos Neuroprotetores / Acidente Vascular Cerebral / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Holanda