Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension.

Marsboom, Glenn; Chen, Zhenlong; Yuan, Yang; Zhang, Yanmin; Tiruppathi, Chinnaswamy; Loyd, James E; Austin, Eric D; Machado, Roberto F; Minshall, Richard D; Rehman, Jalees; Malik, Asrar B

Marsboom, Glenn; Chen, Zhenlong; Yuan, Yang; Zhang, Yanmin; Tiruppathi, Chinnaswamy; Loyd, James E; Austin, Eric D; Machado, Roberto F; Minshall, Richard D; Rehman, Jalees; Malik, Asrar B.

Afiliação

Marsboom G; Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612.
Chen Z; Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612.
Yuan Y; Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612.
Zhang Y; Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612.
Tiruppathi C; Department of Pathology, University of Illinois College of Medicine, Chicago, IL 60612.
Loyd JE; Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612.
Austin ED; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
Machado RF; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232.
Minshall RD; Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612.
Rehman J; Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612.
Malik AB; Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612.

Mol Biol Cell ; 28(9): 1177-1185, 2017 May 01.

Article em En | MEDLINE | ID: mdl-28468941

Assuntos

Caveolina 1/genética; Caveolina 1/metabolismo; Hipertensão Pulmonar/metabolismo; Adenina; Animais; Receptores de Proteínas Morfogenéticas Ósseas Tipo II/genética; Cavéolas/metabolismo; Proliferação de Células/fisiologia; Fibroblastos/metabolismo; Humanos; Hipertensão Pulmonar/etiologia; Hipertensão Pulmonar/genética; Camundongos; Microscopia Eletrônica de Transmissão; Fosforilação; Cultura Primária de Células; Deleção de Sequência/genética; Proteínas Smad Reguladas por Receptor/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caveolina 1 / Hipertensão Pulmonar Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Biol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

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