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Ectopic pregnancy in women with inflammatory bowel disease - a 22 year nationwide cohort study.

Artigo em Inglês | MEDLINE | ID: mdl-28694133

Resumo

BACKGROUND & AIMS: Data on early adverse pregnancy outcomes in inflammatory bowel disease (IBD) such as ectopic pregnancy (EP) remain limited. We assessed the risk of EP in pregnancies of Danish women with IBD compared to all other Danish women over a 22-year period. In addition, we examined the disease-specific risk of EP in pregnancies of women with ulcerative colitis (UC) or Crohn's disease (CD) who underwent IBD-related surgical procedures. METHODS: We obtained nationwide data in all women of child-bearing age who had at least one pregnancy resulting in either an EP, hydatiform mole, induced abortion, miscarriage, or live birth from January 1994 through 2015. The cohorts comprised 7548 UC, 6731 CD and 1,832,732 non-IBD pregnancies. Our primary outcome was EP per pregnancy. We controlled for multiple covariates, including pelvic and abdominal surgery. RESULTS: The risk of EP in pregnancies of women with CD or UC, compared to pregnancies of women without IBD was OR=1.23 (95% CI 1.01 -1.49), and OR= 0.98 (95% CI 0.80 -1.20) respectively. The risk of EP in pregnancies of women with CD or UC who had IBD-related surgery prior to pregnancy compared to pregnancies of women with IBD who had not had surgery was OR=1.49 (95% CI 0.91-2.44) for CD and OR=1.17 (95% CI 0.54 -2.52) for UC. CONCLUSION: We found a statistically significant increased risk of EP in pregnancies of women with CD compared to pregnancies of women without IBD. IBD surgery prior to pregnancy increased EP risk, though this was not statistically significant.