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Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.
Zhuo, Xiaoliang; Wang, Ying-Zi; Yeung, Kap-Sun; Zhu, Juliang; Huang, Xiaohua Stella; Parcella, Kyle E; Eastman, Kyle J; Kadow, John F; Meanwell, Nicholas A; Shu, Yue-Zhong; Johnson, Benjamin M.
Afiliação
  • Zhuo X; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.
  • Wang YZ; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.
  • Yeung KS; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA.
  • Zhu J; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA.
  • Huang XS; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.
  • Parcella KE; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA.
  • Eastman KJ; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA.
  • Kadow JF; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA.
  • Meanwell NA; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA.
  • Shu YZ; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.
  • Johnson BM; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.
Xenobiotica ; 48(12): 1215-1226, 2018 Dec.
Article em En | MEDLINE | ID: mdl-29182424
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Benzamidas / Proteínas não Estruturais Virais / Hepacivirus / Sistema Enzimático do Citocromo P-450 Limite: Animals / Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Benzamidas / Proteínas não Estruturais Virais / Hepacivirus / Sistema Enzimático do Citocromo P-450 Limite: Animals / Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido