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Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.
Miller, Eric J; Jecs, Edgars; Truax, Valarie M; Katzman, Brooke M; Tahirovic, Yesim A; Wilson, Robert J; Kuo, Katie M; Kim, Michelle B; Nguyen, Huy H; Saindane, Manohar T; Zhao, Huanyu; Wang, Tao; Sum, Chi S; Cvijic, Mary E; Schroeder, Gretchen M; Wilson, Lawrence J; Liotta, Dennis C.
Afiliação
  • Miller EJ; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Jecs E; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Truax VM; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Katzman BM; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Tahirovic YA; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Wilson RJ; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Kuo KM; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Kim MB; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Nguyen HH; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Saindane MT; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Zhao H; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Wang T; Bristol-Myers Squibb Research & Development , Princeton, New Jersey 08543, United States.
  • Sum CS; Bristol-Myers Squibb Research & Development , Princeton, New Jersey 08543, United States.
  • Cvijic ME; Bristol-Myers Squibb Research & Development , Princeton, New Jersey 08543, United States.
  • Schroeder GM; Bristol-Myers Squibb Research & Development , Princeton, New Jersey 08543, United States.
  • Wilson LJ; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
  • Liotta DC; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
J Med Chem ; 61(3): 946-979, 2018 02 08.
Article em En | MEDLINE | ID: mdl-29350534
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Tetra-Hidroisoquinolinas / Descoberta de Drogas / Inibidores do Citocromo P-450 CYP2D6 / Absorção Fisico-Química Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Tetra-Hidroisoquinolinas / Descoberta de Drogas / Inibidores do Citocromo P-450 CYP2D6 / Absorção Fisico-Química Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos