S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating &#945;7 nAChR and PI3K / Akt / GSK3ß signal pathway in rats.

Fan, Wenxiang; Li, Xiang; Huang, Liangliang; He, Shucheng; Xie, Zhicheng; Fu, Yuxin; Fang, Weirong; Li, Yunman

S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3ß signal pathway in rats.

Fan, Wenxiang; Li, Xiang; Huang, Liangliang; He, Shucheng; Xie, Zhicheng; Fu, Yuxin; Fang, Weirong; Li, Yunman.

Afiliação

Fan W; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Li X; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Huang L; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
He S; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Xie Z; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Fu Y; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Fang W; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: weirongfang@163.com.
Li Y; State Key Laboratory of Natural Medicines, Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: yunmanlicpu@hotmail.com.

Neurochem Int ; 115: 50-60, 2018 05.

Article em En | MEDLINE | ID: mdl-29355569

Assuntos

Apoptose/efeitos dos fármacos; Isquemia Encefálica/tratamento farmacológico; Pirrolidinas/farmacologia; Acidente Vascular Cerebral/tratamento farmacológico; Animais; Isquemia Encefálica/metabolismo; Sobrevivência Celular/efeitos dos fármacos; Infarto da Artéria Cerebral Média/tratamento farmacológico; Infarto da Artéria Cerebral Média/metabolismo; Masculino; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Fármacos Neuroprotetores/farmacologia; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos Sprague-Dawley; Traumatismo por Reperfusão/metabolismo; Transdução de Sinais/efeitos dos fármacos; Acidente Vascular Cerebral/metabolismo; Ativação Transcricional/efeitos dos fármacos

Palavras-chave

Apoptosis; GSK3ß; Ischemic stroke; S-oxiracetam; α7 nAChR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Isquemia Encefálica / Apoptose / Acidente Vascular Cerebral Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurochem Int Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido

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