A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.

Wang, Xulong; Philip, Vivek M; Ananda, Guruprasad; White, Charles C; Malhotra, Ankit; Michalski, Paul J; Karuturi, Krishna R Murthy; Chintalapudi, Sumana R; Acklin, Casey; Sasner, Michael; Bennett, David A; De Jager, Philip L; Howell, Gareth R; Carter, Gregory W

Wang, Xulong; Philip, Vivek M; Ananda, Guruprasad; White, Charles C; Malhotra, Ankit; Michalski, Paul J; Karuturi, Krishna R Murthy; Chintalapudi, Sumana R; Acklin, Casey; Sasner, Michael; Bennett, David A; De Jager, Philip L; Howell, Gareth R; Carter, Gregory W.

Afiliação

Wang X; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609.
Philip VM; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609.
Ananda G; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032.
White CC; Broad Institute, Cambridge, Massachusetts 02142.
Malhotra A; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032.
Michalski PJ; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032.
Karuturi KRM; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032.
Chintalapudi SR; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609.
Acklin C; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609.
Sasner M; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609.
Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612.
De Jager PL; Broad Institute, Cambridge, Massachusetts 02142.
Howell GR; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York 10027.
Carter GW; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, Maine 04609 gareth.howell@jax.org greg.carter@jax.org.

Genetics ; 209(1): 51-64, 2018 05.

Article em En | MEDLINE | ID: mdl-29507048

Assuntos

Doença de Alzheimer/genética; Teorema de Bayes; Predisposição Genética para Doença; Modelos Lineares; Locos de Características Quantitativas; Idade de Início; Algoritmos; Animais; Estudo de Associação Genômica Ampla; Humanos; Cadeias de Markov; Camundongos; Modelos Biológicos; Método de Monte Carlo; Sequenciamento Completo do Genoma

Palavras-chave

Alzheimer's disease; genome-wide association; whole-genome sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Lineares / Teorema de Bayes / Predisposição Genética para Doença / Locos de Características Quantitativas / Doença de Alzheimer Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Genetics Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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