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Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Balmus, Gabriel; Larrieu, Delphine; Barros, Ana C; Collins, Casey; Abrudan, Monica; Demir, Mukerrem; Geisler, Nicola J; Lelliott, Christopher J; White, Jacqueline K; Karp, Natasha A; Atkinson, James; Kirton, Andrea; Jacobsen, Matt; Clift, Dean; Rodriguez, Raphael; Adams, David J; Jackson, Stephen P.
Afiliação
  • Balmus G; The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.
  • Larrieu D; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Barros AC; The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK. dl437@cam.ac.uk.
  • Collins C; Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. dl437@cam.ac.uk.
  • Abrudan M; The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.
  • Demir M; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Geisler NJ; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Lelliott CJ; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • White JK; The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.
  • Karp NA; The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.
  • Atkinson J; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Kirton A; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Jacobsen M; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Clift D; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Rodriguez R; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Adams DJ; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Jackson SP; Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, CB2 23AT, UK.
Nat Commun ; 9(1): 1700, 2018 04 27.
Article em En | MEDLINE | ID: mdl-29703891
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progéria / Tiazóis / Senilidade Prematura / Instabilidade Genômica / Acetiltransferase N-Terminal A / Hidrazonas Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progéria / Tiazóis / Senilidade Prematura / Instabilidade Genômica / Acetiltransferase N-Terminal A / Hidrazonas Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido