HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.

Chen, Lu; Guo, Piao; He, Yuchao; Chen, Ziye; Chen, Liwei; Luo, Yi; Qi, Lisha; Liu, Yuanyuan; Wu, Qiang; Cui, Yunlong; Fang, Feng; Zhang, Xiaofang; Song, Tianqiang; Guo, Hua

Chen, Lu; Guo, Piao; He, Yuchao; Chen, Ziye; Chen, Liwei; Luo, Yi; Qi, Lisha; Liu, Yuanyuan; Wu, Qiang; Cui, Yunlong; Fang, Feng; Zhang, Xiaofang; Song, Tianqiang; Guo, Hua.

Afiliação

Chen L; Department of tumor cell biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Guo P; Department of Hepatobiliary, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
He Y; Department of tumor cell biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Chen Z; Department of tumor cell biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Chen L; Department of tumor cell biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Luo Y; Department of tumor cell biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Qi L; Department of tumor cell biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Liu Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Wu Q; Department of Genetics, Basic Medical College, Tianjin Medical University, 300070, Tianjin, China.
Cui Y; Department of Hepatobiliary, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Fang F; Department of Hepatobiliary, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Zhang X; Department of Hepatobiliary, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China.
Song T; Department of Medical Laboratory, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Guo H; Department of Hepatobiliary, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 300060, Tianjin, China. tjchi@hotmail.com.

Cell Death Dis ; 9(5): 513, 2018 05 01.

Article em En | MEDLINE | ID: mdl-29725020

Assuntos

Carcinoma Hepatocelular/genética; Transição Epitelial-Mesenquimal/genética; Exossomos/metabolismo; Regulação Neoplásica da Expressão Gênica; Neoplasias Hepáticas/genética; Recidiva Local de Neoplasia/genética; Proteínas rab27 de Ligação ao GTP/genética; Actinas/genética; Actinas/metabolismo; Animais; Antígenos CD/genética; Antígenos CD/metabolismo; Caderinas/genética; Caderinas/metabolismo; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Proliferação de Células; Progressão da Doença; Exossomos/química; Exossomos/patologia; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Metástase Linfática; Sistema de Sinalização das MAP Quinases; Masculino; Camundongos; Camundongos Nus; Recidiva Local de Neoplasia/metabolismo; Recidiva Local de Neoplasia/patologia; Prognóstico; Carga Tumoral; Vimentina/genética; Vimentina/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas rab27 de Ligação ao GTP/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Exossomos / Transição Epitelial-Mesenquimal / Proteínas rab27 de Ligação ao GTP / Neoplasias Hepáticas / Recidiva Local de Neoplasia Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Cell Death Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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