Determination of liraglutide in rat plasma by a selective liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetics study.

Dong, Shiqi; Gu, Yuan; Wei, Guangli; Si, Duanyun; Liu, Changxiao

Dong, Shiqi; Gu, Yuan; Wei, Guangli; Si, Duanyun; Liu, Changxiao.

Afiliação

Dong S; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Gu Y; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Wei G; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Si D; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Liu C; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. Electronic address: liucx@tjipr.com.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1091: 29-35, 2018 Aug 01.

Article em En | MEDLINE | ID: mdl-29803687

Assuntos

Cromatografia Líquida/métodos; Liraglutida/sangue; Liraglutida/farmacocinética; Espectrometria de Massas em Tandem/métodos; Animais; Estabilidade de Medicamentos; Feminino; Modelos Lineares; Liraglutida/química; Masculino; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Sensibilidade e Especificidade

Palavras-chave

LC-MS/MS; Liraglutide; Pharmacokinetics; Rat plasma; Selective

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Espectrometria de Massas em Tandem / Liraglutida Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google