A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo.

Zou, Jianling; Li, Shuang; Chen, Zuhua; Lu, Zhihao; Gao, Jing; Zou, Jianyin; Lin, Xiaoting; Li, Yanyan; Zhang, Cheng; Shen, Lin

Zou, Jianling; Li, Shuang; Chen, Zuhua; Lu, Zhihao; Gao, Jing; Zou, Jianyin; Lin, Xiaoting; Li, Yanyan; Zhang, Cheng; Shen, Lin.

Afiliação

Zou J; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Li S; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Chen Z; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Lu Z; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Gao J; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Zou J; Department of Otolaryngology, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Lin X; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Li Y; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Zhang C; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China. qenya@163.com.
Shen L; Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China. linshenpku@163.com.

Cell Death Dis ; 9(6): 661, 2018 05 31.

Article em En | MEDLINE | ID: mdl-29855512

Assuntos

Antineoplásicos/uso terapêutico; Camptotecina/análogos & derivados; Carcinoma de Células Escamosas do Esôfago/tratamento farmacológico; Irinotecano/uso terapêutico; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Camptotecina/administração & dosagem; Camptotecina/farmacologia; Camptotecina/uso terapêutico; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Dano ao DNA; DNA Topoisomerases Tipo I/metabolismo; Carcinoma de Células Escamosas do Esôfago/patologia; Humanos; Irinotecano/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camptotecina / Irinotecano / Carcinoma de Células Escamosas do Esôfago / Antineoplásicos Limite: Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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