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iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.
Moreno, Cesar L; Della Guardia, Lucio; Shnyder, Valeria; Ortiz-Virumbrales, Maitane; Kruglikov, Ilya; Zhang, Bin; Schadt, Eric E; Tanzi, Rudolph E; Noggle, Scott; Buettner, Christoph; Gandy, Sam.
Afiliação
  • Moreno CL; Department of Neurology, NFL Neurological Care Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Della Guardia L; Department of Psychiatry, Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, 5 E 98th St, New York, NY, 10029, USA.
  • Shnyder V; Department of Medicine, Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Ortiz-Virumbrales M; Department of Medicine, Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Kruglikov I; Department of Neurology, NFL Neurological Care Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Zhang B; New York Stem Cell Foundation Laboratories, New York, NY, 10032, USA.
  • Schadt EE; Icahn Institute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Tanzi RE; Icahn Institute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Noggle S; Genetics and Aging Unit, Harvard Medical School, Massachusetts General Hospital, 114 16th Street, Charlestown, MA, 02129, USA.
  • Buettner C; New York Stem Cell Foundation Laboratories, New York, NY, 10032, USA. snoggle@nyscf.orgu.
  • Gandy S; Department of Medicine, Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Christoph.buettner@mssm.edu.
Mol Neurodegener ; 13(1): 33, 2018 06 26.
Article em En | MEDLINE | ID: mdl-29945658
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Neurônios Colinérgicos / Doença de Alzheimer / Insulina Tipo de estudo: Guideline / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Mol Neurodegener Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Neurônios Colinérgicos / Doença de Alzheimer / Insulina Tipo de estudo: Guideline / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Mol Neurodegener Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido