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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
Coussens, Nathan P; Kales, Stephen C; Henderson, Mark J; Lee, Olivia W; Horiuchi, Kurumi Y; Wang, Yuren; Chen, Qing; Kuznetsova, Ekaterina; Wu, Jianghong; Chakka, Sirisha; Cheff, Dorian M; Cheng, Ken Chih-Chien; Shinn, Paul; Brimacombe, Kyle R; Shen, Min; Simeonov, Anton; Lal-Nag, Madhu; Ma, Haiching; Jadhav, Ajit; Hall, Matthew D.
Afiliação
  • Coussens NP; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Kales SC; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Henderson MJ; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Lee OW; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Horiuchi KY; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.
  • Wang Y; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.
  • Chen Q; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.
  • Kuznetsova E; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.
  • Wu J; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.
  • Chakka S; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Cheff DM; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Cheng KC; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Shinn P; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Brimacombe KR; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Shen M; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Simeonov A; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Lal-Nag M; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Ma H; the Reaction Biology Corporation, Malvern, Pennsylvania 19355.
  • Jadhav A; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and.
  • Hall MD; From the National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 and hallma@mail.nih.gov.
J Biol Chem ; 293(35): 13750-13765, 2018 08 31.
Article em En | MEDLINE | ID: mdl-29945974

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Nucleossomos / Histona-Lisina N-Metiltransferase / Avaliação Pré-Clínica de Medicamentos / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Nucleossomos / Histona-Lisina N-Metiltransferase / Avaliação Pré-Clínica de Medicamentos / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos