A simple, sensitive, and high-throughput LC-APCI-MS/MS method for simultaneous determination of vitamin K<sub>1</sub>, vitamin K<sub>1</sub> 2,3-epoxide in human plasma and its application to a clinical pharmacodynamic study of warfarin.

Hu, Kuan; Li, Yan; Ding, Ru; Zhai, Yu; Chen, Lin; Qian, Wei; Yang, Jin

A simple, sensitive, and high-throughput LC-APCI-MS/MS method for simultaneous determination of vitamin K₁, vitamin K₁ 2,3-epoxide in human plasma and its application to a clinical pharmacodynamic study of warfarin.

Hu, Kuan; Li, Yan; Ding, Ru; Zhai, Yu; Chen, Lin; Qian, Wei; Yang, Jin.

Afiliação

Hu K; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Li Y; Department of Pharmacy, Xinjiang Medical University, Urumchi 830011, China.
Ding R; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Zhai Y; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Chen L; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Qian W; Department of Phase I Clinical Trials, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: yuanyue_qw@126.com.
Yang J; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address: yjcpu@yahoo.com.

J Pharm Biomed Anal ; 159: 82-91, 2018 Sep 10.

Article em En | MEDLINE | ID: mdl-29980023

Assuntos

Anticoagulantes/farmacocinética; Ensaios de Triagem em Larga Escala/métodos; Espectrometria de Massas em Tandem/métodos; Vitamina K 1/análogos & derivados; Vitamina K 1/sangue; Varfarina/farmacocinética; Cromatografia Líquida de Alta Pressão/métodos; Cromatografia Líquida de Alta Pressão/normas; Cromatografia Líquida/métodos; Cromatografia Líquida/normas; Ensaios de Triagem em Larga Escala/normas; Humanos; Espectrometria de Massas em Tandem/normas

Palavras-chave

Coagulation; LC-APCI-MS/MS; Vitamin K; Vitamin K epoxide; Warfarin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina K 1 / Varfarina / Espectrometria de Massas em Tandem / Ensaios de Triagem em Larga Escala / Anticoagulantes Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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