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Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.
Bononi, Giulia; Granchi, Carlotta; Lapillo, Margherita; Giannotti, Massimiliano; Nieri, Daniela; Fortunato, Serena; Boustani, Maguie El; Caligiuri, Isabella; Poli, Giulio; Carlson, Kathryn E; Kim, Sung Hoon; Macchia, Marco; Martinelli, Adriano; Rizzolio, Flavio; Chicca, Andrea; Katzenellenbogen, John A; Minutolo, Filippo; Tuccinardi, Tiziano.
Afiliação
  • Bononi G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Granchi C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy. Electronic address: carlotta.granchi@unipi.it.
  • Lapillo M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Giannotti M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Nieri D; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, CH-3012, Bern, Switzerland.
  • Fortunato S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Boustani ME; Pathology Unit, Department of Molecular Biology and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, Aviano (PN), Italy; Doctoral School in Molecular Biomedicine, University of Trieste, 34100, Trieste, Italy.
  • Caligiuri I; Pathology Unit, Department of Molecular Biology and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, Aviano (PN), Italy.
  • Poli G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Carlson KE; Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL, 61801, USA.
  • Kim SH; Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL, 61801, USA.
  • Macchia M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Martinelli A; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Rizzolio F; Pathology Unit, Department of Molecular Biology and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, Aviano (PN), Italy; Department of Molecular Sciences and Nanosystems, Ca' Foscari University, Venezia, 30123, Italy.
  • Chicca A; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, CH-3012, Bern, Switzerland.
  • Katzenellenbogen JA; Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL, 61801, USA.
  • Minutolo F; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
  • Tuccinardi T; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Eur J Med Chem ; 157: 817-836, 2018 Sep 05.
Article em En | MEDLINE | ID: mdl-30144699
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Inibidores Enzimáticos / Descoberta de Drogas / Monoacilglicerol Lipases / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália País de publicação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Inibidores Enzimáticos / Descoberta de Drogas / Monoacilglicerol Lipases / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália País de publicação: França