Caffeic acid attenuates rat liver injury after transplantation involving PDIA3-dependent regulation of NADPH oxidase.

Mu, Hong-Na; Li, Quan; Fan, Jing-Yu; Pan, Chun-Shui; Liu, Yu-Ying; Yan, Li; Sun, Kai; Hu, Bai-He; Huang, Dan-Dan; Zhao, Xin-Rong; Chang, Xin; Wang, Chuan-She; He, Shu-Ya; He, Ke; Yang, Bao-Xue; Han, Jing-Yan

Mu, Hong-Na; Li, Quan; Fan, Jing-Yu; Pan, Chun-Shui; Liu, Yu-Ying; Yan, Li; Sun, Kai; Hu, Bai-He; Huang, Dan-Dan; Zhao, Xin-Rong; Chang, Xin; Wang, Chuan-She; He, Shu-Ya; He, Ke; Yang, Bao-Xue; Han, Jing-Yan.

Afiliação

Mu HN; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's R
Li Q; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Fan JY; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Pan CS; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Liu YY; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Yan L; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Sun K; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Hu BH; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Huang DD; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chi
Zhao XR; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Chang X; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Beijing 100191, China; Key Laboratory of Stasis and Phlegm, State Administratio
Wang CS; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chi
He SY; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chi
He K; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chi
Yang BX; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China. Electronic address: baoxue@bjmu.edu.cn.
Han JY; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China; Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China; Key Laboratory of Microcirculation, State Administration of Traditional Chi

Free Radic Biol Med ; 129: 202-214, 2018 12.

Article em En | MEDLINE | ID: mdl-30218773

Assuntos

Antioxidantes/farmacologia; Ácidos Cafeicos/farmacologia; Transplante de Fígado; NADPH Oxidases/genética; Isomerases de Dissulfetos de Proteínas/genética; Traumatismo por Reperfusão/prevenção & controle; Animais; Antioxidantes/isolamento & purificação; Apoptose/efeitos dos fármacos; Ácidos Cafeicos/isolamento & purificação; Hipóxia Celular/genética; Linhagem Celular; Regulação da Expressão Gênica; Hepatócitos/citologia; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Masculino; NADPH Oxidases/metabolismo; Isomerases de Dissulfetos de Proteínas/antagonistas & inibidores; Isomerases de Dissulfetos de Proteínas/metabolismo; Subunidades Proteicas/genética; Subunidades Proteicas/metabolismo; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Ratos; Ratos Sprague-Dawley; Traumatismo por Reperfusão/genética; Traumatismo por Reperfusão/metabolismo; Traumatismo por Reperfusão/patologia; Salvia miltiorrhiza/química; Transdução de Sinais; Transplante Homólogo

Palavras-chave

Apoptosis; Liver microcirculatory disturbance; Salvia miltiorrhiza; Superoxide anion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Cafeicos / Traumatismo por Reperfusão / Transplante de Fígado / NADPH Oxidases / Isomerases de Dissulfetos de Proteínas / Antioxidantes Limite: Animals Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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