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Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.
Lord, Simon R; Cheng, Wei-Chen; Liu, Dan; Gaude, Edoardo; Haider, Syed; Metcalf, Tom; Patel, Neel; Teoh, Eugene J; Gleeson, Fergus; Bradley, Kevin; Wigfield, Simon; Zois, Christos; McGowan, Daniel R; Ah-See, Mei-Lin; Thompson, Alastair M; Sharma, Anand; Bidaut, Luc; Pollak, Michael; Roy, Pankaj G; Karpe, Fredrik; James, Tim; English, Ruth; Adams, Rosie F; Campo, Leticia; Ayers, Lisa; Snell, Cameron; Roxanis, Ioannis; Frezza, Christian; Fenwick, John D; Buffa, Francesca M; Harris, Adrian L.
Afiliação
  • Lord SR; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NH
  • Cheng WC; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Liu D; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Gaude E; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.
  • Haider S; Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
  • Metcalf T; Institute of Translational Medicine, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA, UK.
  • Patel N; Department of Nuclear Medicine, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.
  • Teoh EJ; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK; Department of Nuclear Medicine, Oxford University Hospitals NHS Founda
  • Gleeson F; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK; Department of Nuclear Medicine, Oxford University Hospitals NHS Foundation Trust, Ch
  • Bradley K; Department of Nuclear Medicine, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.
  • Wigfield S; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Zois C; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • McGowan DR; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Ah-See ML; Department of Oncology, Luton and Dunstable Hospital, Luton, UK.
  • Thompson AM; Department of Breast Surgical Oncology, MD Anderson Cancer Centre, Houston, TX 77030, USA.
  • Sharma A; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Bidaut L; College of Science, University of Lincoln, Lincoln LN6 7TS, UK; Clinical Research Imaging Facility, University of Dundee, Ninewells Hospital, Dundee DD2 1SY, UK.
  • Pollak M; Department of Oncology, McGill University, Montreal, QC H3T 1E2, Canada.
  • Roy PG; Breast Surgery Unit, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.
  • Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • James T; Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • English R; Oxford Breast Imaging Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, UK.
  • Adams RF; Oxford Breast Imaging Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, UK.
  • Campo L; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Ayers L; Department of Clinical and Laboratory Immunology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.
  • Snell C; Department of Anatomical Pathology, Mater Research Institute, Brisbane 4101, Australia.
  • Roxanis I; Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • Frezza C; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.
  • Fenwick JD; Institute of Translational Medicine, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA, UK.
  • Buffa FM; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
  • Harris AL; Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NH
Cell Metab ; 28(5): 679-688.e4, 2018 11 06.
Article em En | MEDLINE | ID: mdl-30244975
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Redes e Vias Metabólicas / Hipoglicemiantes / Metformina / Antineoplásicos Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Redes e Vias Metabólicas / Hipoglicemiantes / Metformina / Antineoplásicos Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos