HIF-1&#945; inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.

Li, Zuo-Lin; Lv, Lin-Li; Tang, Tao-Tao; Wang, Bin; Feng, Ye; Zhou, Le-Ting; Cao, Jing-Yuan; Tang, Ri-Ning; Wu, Min; Liu, Hong; Crowley, Steven D; Liu, Bi-Cheng

HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.

Li, Zuo-Lin; Lv, Lin-Li; Tang, Tao-Tao; Wang, Bin; Feng, Ye; Zhou, Le-Ting; Cao, Jing-Yuan; Tang, Ri-Ning; Wu, Min; Liu, Hong; Crowley, Steven D; Liu, Bi-Cheng.

Afiliação

Li ZL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Lv LL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu. Electronic address: lvlinli2000@hotmail.com.
Tang TT; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Wang B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Feng Y; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Zhou LT; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Cao JY; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Tang RN; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Wu M; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Liu H; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu.
Crowley SD; Division of Nephrology, Department of Medicine, Duke University, Durham VA Medical Centers, Durham, North Carolina, USA.
Liu BC; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu. Electronic address: liubc64@163.com.

Kidney Int ; 95(2): 388-404, 2019 02.

Article em En | MEDLINE | ID: mdl-30551896

Assuntos

Células Epiteliais/imunologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Macrófagos/imunologia; MicroRNAs/metabolismo; Nefrite Intersticial/imunologia; Animais; Comunicação Celular/imunologia; Hipóxia Celular/genética; Hipóxia Celular/imunologia; Reprogramação Celular/genética; Reprogramação Celular/imunologia; Modelos Animais de Doenças; Células Epiteliais/citologia; Células Epiteliais/metabolismo; Exossomos/imunologia; Exossomos/metabolismo; Regulação da Expressão Gênica/imunologia; Humanos; Túbulos Renais/citologia; Túbulos Renais/imunologia; Macrófagos/metabolismo; Masculino; Camundongos; Nefrite Intersticial/patologia; Transdução de Sinais/genética; Transdução de Sinais/imunologia; Proteína 3 Induzida por Fator de Necrose Tumoral alfa/genética; Proteína 3 Induzida por Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

exosome; hypoxia inducible factor-1α (HIF-1α); macrophages; microRNA-23a; tubular epithelial cells; tubulointerstitial inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Células Epiteliais / Subunidade alfa do Fator 1 Induzível por Hipóxia / Macrófagos / Nefrite Intersticial Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Kidney Int Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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