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High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.
Woo, Laura A; Tkachenko, Svyatoslav; Ding, Mei; Plowright, Alleyn T; Engkvist, Ola; Andersson, Henrik; Drowley, Lauren; Barrett, Ian; Firth, Mike; Akerblad, Peter; Wolf, Matthew J; Bekiranov, Stefan; Brautigan, David L; Wang, Qing-Dong; Saucerman, Jeffrey J.
Afiliação
  • Woo LA; Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, USA.
  • Tkachenko S; Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, USA.
  • Ding M; Discovery Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Plowright AT; Medicinal Chemistry, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Engkvist O; Discovery Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Andersson H; Discovery Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Drowley L; Bioscience Heart Failure, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Barrett I; Discovery Sciences, IMED Biotech Unit, AstraZeneca Cambridge, UK.
  • Firth M; Discovery Sciences, IMED Biotech Unit, AstraZeneca Cambridge, UK.
  • Akerblad P; Bioscience Heart Failure, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Wolf MJ; Department of Medicine and Robert M. Berne Cardiovascular Research Center, University of Virginia, USA.
  • Bekiranov S; Department of Biochemistry and Molecular Genetics, University of Virginia, USA.
  • Brautigan DL; Center for Cell Signaling, Department of Microbiology, Immunology & Cancer Biology, University of Virginia, USA.
  • Wang QD; Bioscience Heart Failure, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
  • Saucerman JJ; Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, USA. Electronic address: jsaucerman@virginia.edu.
J Mol Cell Cardiol ; 127: 204-214, 2019 02.
Article em En | MEDLINE | ID: mdl-30597148

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cálcio Tipo L / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: J Mol Cell Cardiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cálcio Tipo L / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: J Mol Cell Cardiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido