P53 knockout mice are protected from cocaine-induced kindling behaviors via inhibiting mitochondrial oxidative burdens, mitochondrial dysfunction, and proapoptotic changes.

Mai, Huynh Nhu; Sharma, Naveen; Jeong, Ji Hoon; Shin, Eun-Joo; Pham, Duc Toan; Trinh, Quynh Dieu; Lee, Yu Jeung; Jang, Choon-Gon; Nah, Seung-Yeol; Bing, Guoying; Kim, Hyoung-Chun

Mai, Huynh Nhu; Sharma, Naveen; Jeong, Ji Hoon; Shin, Eun-Joo; Pham, Duc Toan; Trinh, Quynh Dieu; Lee, Yu Jeung; Jang, Choon-Gon; Nah, Seung-Yeol; Bing, Guoying; Kim, Hyoung-Chun.

Afiliação

Mai HN; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Sharma N; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Jeong JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea. Electronic address: jhjeong3@cau.ac.kr.
Shin EJ; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Pham DT; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Trinh QD; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Lee YJ; Clinical Pharmacy, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Jang CG; Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Nah SY; Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea.
Bing G; Anatomy and Neurobiology, University of Kentucky Medical Center, MN208, 800 Rose Streets, Lexington, KY, 40536, USA.
Kim HC; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. Electronic address: kimhc@kangwon.ac.kr.

Neurochem Int ; 124: 68-81, 2019 03.

Article em En | MEDLINE | ID: mdl-30597180

Assuntos

Apoptose/fisiologia; Cocaína/toxicidade; Excitação Neurológica/metabolismo; Mitocôndrias/metabolismo; Estresse Oxidativo/fisiologia; Proteína Supressora de Tumor p53/deficiência; Animais; Apoptose/efeitos dos fármacos; Excitação Neurológica/efeitos dos fármacos; Excitação Neurológica/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/genética; Oxirredução/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Distribuição Aleatória; Proteína Supressora de Tumor p53/antagonistas & inibidores; Proteína Supressora de Tumor p53/genética

Palavras-chave

Cocaine-kindling (convulsive) behaviors; Hippocampus; Mitochondrial dysfunction; Oxidative stress; Pro-apoptosis; p53 knockout mice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Cocaína / Apoptose / Estresse Oxidativo / Excitação Neurológica / Mitocôndrias Limite: Animals Idioma: En Revista: Neurochem Int Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

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