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Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies.
Chen, Han; Huffman, Jennifer E; Brody, Jennifer A; Wang, Chaolong; Lee, Seunggeun; Li, Zilin; Gogarten, Stephanie M; Sofer, Tamar; Bielak, Lawrence F; Bis, Joshua C; Blangero, John; Bowler, Russell P; Cade, Brian E; Cho, Michael H; Correa, Adolfo; Curran, Joanne E; de Vries, Paul S; Glahn, David C; Guo, Xiuqing; Johnson, Andrew D; Kardia, Sharon; Kooperberg, Charles; Lewis, Joshua P; Liu, Xiaoming; Mathias, Rasika A; Mitchell, Braxton D; O'Connell, Jeffrey R; Peyser, Patricia A; Post, Wendy S; Reiner, Alex P; Rich, Stephen S; Rotter, Jerome I; Silverman, Edwin K; Smith, Jennifer A; Vasan, Ramachandran S; Wilson, James G; Yanek, Lisa R; Redline, Susan; Smith, Nicholas L; Boerwinkle, Eric; Borecki, Ingrid B; Cupples, L Adrienne; Laurie, Cathy C; Morrison, Alanna C; Rice, Kenneth M; Lin, Xihong.
Afiliação
  • Chen H; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Precision Health, School of Public Health and School of Biomedical Informatics, The Univ
  • Huffman JE; Center for Population Genomics, VA Boston Healthcare System, Jamaica Plain, MA 02130, USA.
  • Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
  • Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Lee S; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Li Z; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
  • Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.
  • Bowler RP; Division of Pulmonary Medicine, Department of Medicine, National Jewish Health, Denver, CO 80206, USA.
  • Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.
  • de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Glahn DC; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT 06106, USA.
  • Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Johnson AD; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA 01702, USA.
  • Kardia S; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Lewis JP; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Liu X; USF Genomics, College of Public Health, University of South Florida, Tampa, FL 33612, USA.
  • Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, MD 21201, USA.
  • O'Connell JR; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Post WS; Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA.
  • Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
  • Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Vasan RS; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA 01702, USA; Sections of Preventive Medicine and Epidemiology, and of Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; Department of Epidemiology, Bo
  • Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  • Smith NL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and
  • Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Borecki IB; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Cupples LA; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
  • Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Rice KM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Lin X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Statistics, Harvard University, Cambridge, MA 02138, USA. Electronic address: xlin@hsph.harvard.edu.
Am J Hum Genet ; 104(2): 260-274, 2019 02 07.
Article em En | MEDLINE | ID: mdl-30639324
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudos de Associação Genética / Sequenciamento Completo do Genoma / Modelos Genéticos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Am J Hum Genet Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudos de Associação Genética / Sequenciamento Completo do Genoma / Modelos Genéticos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Am J Hum Genet Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos