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Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
Chen, Hua-Dong; Chen, Chuan-Huizi; Wang, Yu-Ting; Guo, Ne; Tian, Yu-Nan; Huan, Xia-Juan; Song, Shan-Shan; He, Jin-Xue; Miao, Ze-Hong.
Afiliação
  • Chen HD; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Chen CH; University of Chinese Academy of Sciences, Beijing, China.
  • Wang YT; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Guo N; University of Chinese Academy of Sciences, Beijing, China.
  • Tian YN; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Huan XJ; University of Chinese Academy of Sciences, Beijing, China.
  • Song SS; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • He JX; University of Chinese Academy of Sciences, Beijing, China.
  • Miao ZH; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Int J Cancer ; 145(3): 714-727, 2019 08 01.
Article em En | MEDLINE | ID: mdl-30675909
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Neoplasias / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Neoplasias / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos